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KMID : 0438219780150010001
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Korea University Medical Journal
1978 Volume.15 No. 1 p.1 ~ p.12
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An Experimental Study of the Effects of Prostaglandin F₂α and Progesterone on the Catecholamine Content in Uterine and Stomach Tissue of Mature Female Rabbits
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Abstract
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Prostaglandin FZa has been studied by many scholars and used for induction of labor which is supposed to be far superior to any preexisting agent or method. Despite the fact that few patients experience allergic reactions, hypertension. bronchospasm, nausea, vomiting, cramps, and diarrhea, the efficacy and relative safety of the drug establish it as superior to intra-amniotic instillation of hypertonic saline.
Prostaglandins are formed from free essential fatty acids within the cell in a sequence of complex enzyme reactions,´-´and they are released in response to nervous, chemical, and mechanical stimuli.
An attempt was made to clarify the effects of prostaglandin FZa and progesterone on the catecholamine content ´in uterine and stomach tissue of mature female albino rabbits weighing approximately 2.0 kg.
A group of albino rabbits was conditioned with 100 jug/kg of prostaglandin FZa and another group with 50 mg/kg "of progesterone.
Catecholamine` content wa`s determined by Shore and Olin method and the results obtained` were as follows: =
1. The catecholamine content in normal uterine tissue was 0.330.06 Pg/gm while that of stomach tissue was 0.060:02 pg/gm. It showed that the catecholamine content in uterine tissue was higher than in stomach tissue.
2. In prostaglandin FZa conditioned group, the catecholamine content in uterine tissue was 1.25 0.54 ug /gm, while that of stomach tissue was 0.130.08 fig/gm. It was, therefore, shown that the catecholamine content in uterine tissue was increased significantly, while that of stomach tissue showed slight increase in pt6staglandin´F2a conditioned group:
3. In progesterone: conditioned. group, `66 catecholamine -content in uterine "tissue was´ D:21MIf I g/gm and its content in stomach `tissue was 0.090: 02 p9/gm
The catecholamine content in uterine tissue showed marked decrease in progesterone conditioned group and showed, even more, decrease compared with prostaglandin Fza conditioned group. There was a slight increase--in stomach in progesterone conditioned group than normal control group, however, there was no significant change compared with prostaglandin Fza conditioned group.
4. The catecholamine content in uterine tissue was markedly increased in prostaglandin %;a conditioned group, while there showed decrease in progesterone conditioned group.
5. The catecholamine content in stomach tissue showed marked increase in prostaglandin FLa conditioned group, and, also, showed increase in progesterone group.
6. The catecholamine content in uterine tissue was higher than that of stomach tissue in normal control group.
There was a marked increase in uterine tissue in prostaglandin Fza conditioned group, and, also, showed increase in stomach tissue.
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KEYWORD
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